Esculetin Restores Mitochondrial Dysfunction and Reduces Allergic Asthma Features in Experimental Murine Model

Features in Experimental Murine Model Dysfunction and Reduces Allergic Asthma Esculetin Restores Mitochondrial

Effects of vitamin E on mitochondrial dysfunction and asthma features in an experimental allergic murine model.

We showed recently that IL-4 causes mitochondrial dysfunction in allergic asthma. IL-4 is also known to induce 12/15-lipoxygenase (12/15-LOX), a potent candidate molecule in asthma. Because vitamin E (Vit-E) reduces IL-4 and inhibits 12/15-LOX in vitro, here we tested the hypothesis that Vit-E may be effective in restoring key mitochondrial dysfunctions, thus alleviating asthma features in an e...

Innovative Methodology Effects of vitamin E on mitochondrial dysfunction and asthma features in an experimental allergic murine model

Ulaganathan Mabalirajan, Jyotirmoi Aich, Geeta Devi Leishangthem, Surendra Kumar Sharma, Amit Kumar Dinda, and Balaram Ghosh Molecular Immunogenetics Laboratory, Institute of Genomics and Integrative Biology, Delhi; and Division of Renal Pathology, Department of Pathology, and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, All India Institute of Medical Science...

Induction of experimental allergic asthma in cat

19 cats were nper-sensitized to allergic asthma by receiving a concomitant spray ang injection of ovalbumin (10% fresh egg-white in normal saline) every other days for four weeks.then animals were anesthetized and left femoral artery cannulation performed to record atrerial pressure and take blood samples.left femoral vein was cannulated to infuse nutritional fluids and grugs as needed.trachea ...

Study of Chenopodium Album Allergenic Extract to Induce Allergic Asthma in Murine Model

Background: The incidence of allergic and asthmatic diseases has been continuously increased in both industrial and developing countries. Extracts from various known allergens are used for the diagnostic and therapeutic purposes. Objective: To investigate the effects of an extract prepared from Chenopodium album (Ch.A.) pollen to induce allergic asthma in BALB/C mice. Methods: BALB/C mice were ...